4/28/2023 0 Comments Dextran mr contrast![]() Tri-tyrosine residues distributed along the backbone. final compound 4 (PTriTyr) is a dextran based polymer with The addition of sodium cyanoborohydride (NaBH3CN). With the carbonyl groups via the primary amine to form a Schiff’sīase 3 which was further reduced in the same pot to an amine by The dark and the derivative named Pox 2 was obtained after Oxidised with sodium periodate (NaIO4) at room temperature in Possibility of using modified polysaccharides as targeting moietiesįor the imaging and/or treatment of vascular diseases.įirst, a dextran backbone already bearing Gd–DOTA 1 was Scheme 1 Synthesis of trityrosine bearing contrast agent. Modification, physical and chemical characterization, in vitro and W Electronic supplementary information (ESI) available: Chemical UMR 6270 & FR 3038 76821, Mont Saint Aignan, France Guerbet, Research Division, Aulnay-Sous-Bois, F-93600, France Universite´ Lyon 1, 43 Boulevard du 11 Novembre 1918, University Paris 7, Paris, F-75877, France Inserm, U698, Cardiovascular Bio-engineering, CHU X. Phenylalanines or tyrosines could generate a structure mimickingĭ-4F and, as a consequence, ApoA1 affinity to lipids, raising the This long circulating blood pool contrast agent isĭevoid of biospecificity for the arterial wall.14,15 We haveĬonsidered in the present work that the substitution of P717 with Substituted with carboxylate groups and Gd–DOTA13 (Scheme 1Īnd ESIw). Here the starting compound, named P717, is made of dextran Phenylalanine residues able to interact with lipids of lipoproteins11 Models.8–10 This product is a 18 amino acid peptide that formsĪn amphiphatic a-helix. Named ETC-216 or MDCO-216), show affinity to lipids.4–6 TheyĬould also self-assemble and link to apolipoproteins.7 Moreover,ĭ-4F has been shown to reduce the lipid core in vivo in animal (ApoA1) peptidomimetics, such as D-4F or ApoA1 milano (also Lipid core in the atherosclerotic plaque. Injection and have a lipophilic moiety to promote retention in the The MR contrast agent must be water soluble for intravascular Targeting the lipid core is challenging as Research activities have focused on contrast agents directedĪgainst plaque activity or inflammation markers such as macrophages or selectins,2,3 identifying the lipid rich necrotic core Great improvement for the patient follow-up.1 While major Identifying these plaques before they rupture would be a Main ischemic events are caused by the rupture of vulnerable plaques, composed of a large lipid core under a fine fibrousĬape. In vivo evaluation in mice of a new tri-tyrosine conjugated MRĬontrast agent, which may help to identify vulnerable plaques inĪtherosclerosis by targeting the lipid core.Ītherosclerosis is the leading cause of disease in western countries. This communication reports the synthesis, characterization and Received 14th February 2011, Accepted 16th March 2011 Luc Picton,e Didier Letourneurab and Frédéric Chaubetab Synthesis and evaluation of a tri-tyrosine decorated dextran MR contrastĪnne Beilvert,*ab Roger Vassy,ab Emmanuelle Canet-Soulas,c Olivier Rousseaux,d Downloaded by University of Chicago on 21:58:53. They are effectively internalised by human normal and cancer cells and demonstrate dose-dependent selective cytotoxicity to cancer cells.View Article Online / Journal Homepage / Table of Contents for this issueĬite this: Chem. These ultra-small (4–6 nm) Ce₀.₉Gd₀.₁O₁.₉₅ nanoparticles have been shown to possess excellent colloidal stability and high r₁-relaxivity (3.6 mM⁻¹ s⁻¹). Here, we report on a new type of theranostic MRI contrast, namely dextran stabilised, gadolinium doped cerium dioxide nanoparticles. Thus, there is an urgent need to develop a new generation of MRI contrasts that are safe and that have high selectivity in tissue accumulation with improved local contrast. The main causes of concern are possible gadolinium deposition in the brain and the development of systemic nephrogenic fibrosis after repeated use of MRI contrasts. The safety of previously approved contrast agents is questionable and is being re-assessed. 6586-6599 ISSN: 2050-7518 Subject: brain, ceric oxide, chemistry, cytotoxicity, dextran, dose response, fibrosis, gadolinium, humans, magnetism, nanoceria Abstract: Gd-based complexes are widely used as magnetic resonance imaging (MRI) contrast agents. Ivanov Source: Journal of materials chemistry B 2021 v.9 no.33 pp. Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T₁ relaxivity and selective cytotoxicity to cancer cells Author: A.
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