![]() But what really marks progress is something else in the background: throughout history, both societies and individuals have gained a greater capacity to carry out projects. Progress has traditionally been measured based on purchasing power or per capita income. Economic theory and prosperity indicators How will democracy be reshaped and revitalized by projects? 5. One-third of the convention’s membership consisted of members of the Irish parliament, and two-thirds were made up of ordinary citizens who were selected at random from the Irish population and worked on the project in a limited time frame. The novelty was that each topic was being tackled through a project. The Convention on the Constitution, established by the Irish government in 2012, addressed a number of potential constitutional reforms, including whether to change the electoral system or to reform the parliament. One of the most revolutionary experiments was carried out in Ireland. The current crisis that we are seeing in political systems around the world has lead academics and others to propose new ways of governing countries. How will our organizations be restructured and governed to maximize the value creation and impact of projects? 4. Conversely, ignorance of the accountability duties by directors in these matters is a weakness in corporations, destroying a vast amount of value and often bringing corporations to the verge of collapse. When organizations execute too many strategic projects without clear prioritization from the top, they will be spread too thinly: teams will fight for resources, commitments to contribute to certain projects will not be respected, and most projects will fail to meet their initial cost, time and benefit estimates. In the current turbulent times, providing direction and prioritizing initiatives have become essential competencies for boards. Corporate governanceīoards play a critical role in value creation and long-term organizational success. What does the project career mean for employers and employees? 3. This sort of career is best approached as a set of projects in which we apply the lessons we have learned from previous jobs, companies and industries while developing ourselves for our next career move, often not known in advance. Today we are likely to work for several companies, and at some point we will most probably become self-employed, working primarily on projects. Throughout the 20th century, most people worked for a single company. Not so long ago, professional careers were made in only one organization. Applying theories and experimenting through projects has proven to be a much better learning method, and soon it will become the norm./ What are the implications of this for how we are taught and the organizations that provide education? 2. starting from early ages, apply the concept of teaching projects. Educationįor centuries, learning was achieved by memorizing hefty books and mountains of written material. The main implications, which I will cover in this book are as follows: 1. Every aspect of our lives is becoming a set of projects. And this massive disruption is only impacting the way organizations are managed. The emergence of projects as the economic engine of our times is silent but incredibly disruptive and powerful. Today, we hear from Antonio Nieto-Rodriguez on How to succeed in a project-driven world and how his book, The Project Revolution, can help.
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4/28/2023 0 Comments Raft wars cool math gamesUse your mouse to aim and shoot at the pirates. Or if you'd like to continue the journey, check out the second instalment in the series, Raft Wars 2! Developer If you manage to pull yourself away from this game, be sure to check our other similar games in our skill games category. His story hit the news and now pirates from all around the world want to fight this little guy for his loot With the help of his baby brother and dog, Simon is set on defending his rightfully earned treasure. Simon made the discovery of diamonds while playing in the sand one day. Test your aim and enjoy the funny characters, animations and amusing storyline of Raft Wars. Raft Wars: Help Simon defend his treasure from pirates in this raft wars game. Now the fish will have to deal with those nasty pirates instead. If calculated properly, you'll hit the pirates and bowl them over, sending them to the depths of the sea. To knock out the pirates, simply aim your weapon with your mouse and then adjust the power of your shot. Play this new version of the world-famous turn-based online game Raft Wars, a unique and fun artillery game with a colourful comic style. Don't let them gang up on you! You will also have a chance to improve your raft and your weapons as you unlock new items and characters. As you pass the levels and make progress, they'll call upon their pirate friends. With each level, the pirates will grow meaner and more desperate as they try to hit you harder. In Raft Wars, your aim is to knock out every pirate you encounter in the levels as you avoid getting knocked out of your own raft yourself. Jump onto the raft and take control as you try to fend off the mean pirates in Raft Wars. These pirates are keen on taking the treasure from him, even if some sandcastles will get destroyed in the process! Unlucky for them, Simon and his brother are not willing to give away their newly found wealth so quickly and without a fight. News traveled fast and greedy pirates heard of his discovery. He never thought that he'd get sucked into an adventure until he found a secret, hidden treasure. A rollicking game with raft wars, is waiting for you! Let’s get started! After the game is loaded, you click ” Go ” button which is on the lower-right corner of the game screen.Experience the adventure of Raft Wars! It was a pleasant and warm day when Simon decided to play in the sand just like any kid would do. To take back their treasure, they must beat the coast guard and the other people. How to take back the treasure in raft Wars? If you want to skip the game intro, you can click the ” Skip ” button which is on the lower-right corner of the game screen. Now they’re on a mission to put the water park out of business so they can get get back their gold!Ī rollicking game with raft wars, is waiting for you! Let’s get started! After the game is loaded, you click ” Go ” button which is on the lower-right corner of the game screen. Simon and his brother return from a well-deserved holiday only to find a water park on top of where they’ve hidden their buried treasure. Raft Wars 2 is an action-packed shooting game created by Martijn Kunst as the sequel to the hit game Raft Wars. Or if you'd like to continue the journey, check out the second instalment in the series, Raft Wars 2 Developer. Sneak past the guards so you can retrieve your lost treasure. If you manage to pull yourself away from this game, be sure to check our other similar games in our skill games category. Play Raft Wars 2 on Kizi! Cause mayhem at the waterpark by shooting your tennis ball gun. The players survive together on the raft, build it up with the resources they find and defend it against the environmental dangers. The game officially supports 8 players but the true limit is the server hardware the host uses. ![]() How many players can play Raft together 2021? Cause havoc at the water park, fight with security, knock paint into the pool, upgrade your raft and raise as much commotion as possible! Use your wits to determine the physics of this addictive and indepth cannon game. Hit from long ranges to deal more damage.Īlthough the Raft ending isn’t complete, there is still quite a bit to do in the survival crafting game.Ĭoming October 8th! “The Second Chapter” is coming out October 8th and we have put together a trailer to show what it is all about! Get ready Rafters, soon it is time to sail to new adventures! What is raft wars2?.If you have 1 player try to finish the other enemies using power ups.Upgrade more often before battle if you have gold.Enter the Password if prompted.ġ0 Strategies for RAFT WARS and RAFT WARS 2 The other Person have to select “Join World”, the friends game will be shown. One Person have to either select “New Worlds” or “Load World”, ensure the “Friends can join” is selected and if you enter a Password, that you share it with the Friend. How do you play Raft Wars multiplayer with friends? They are also the creators of Raft Wars and Raft Wars Multiplayer. Raft Wars 2 is created by Martijn Kunst and TinyDobbins, based in the Netherlands. RAFT WARS MULTIPLAYER – Play Raft Wars Multiplayer on Poki. 4/28/2023 0 Comments Twitch stronghold warlords![]() We have an important announcement to make regarding the release date of Stronghold: Warlords to share with you all today. Hopefully, more gameplay will be provided in the coming weeks before launch so stay tuned. Along with the campaign and multiplayer, Steam Workshop support will also be available at launch for user-created maps. Two Warlords - Subdue the enemy without fighting using new perks, edicts and upgrades. Two players can team up and fight the AI or even work together to manage a castle with one person managing the army and the other working on the economy. Six Missions - Put your Stronghold skills to the test with a series of challenging scenarios. Stronghold: Warlords offers quite a bit in terms of multiplayer functionality. While it contemplated delayed multiplayer and releasing it a future update, the developer wants to stick to its promise of having multiplayer ready for launch and providing a “full experience.” The prime cause of the second delay is multiplayer.Īccording to the developer on Twitter, the multiplayer mode is “simply not ready to be released yet.” It ran into some “unexpected issues” and needs more time to fix them. This is after it was delayed from its September 2020 release date. Updated Fortnite Streamer Grefg Destroys Twitch Concurrent Viewers Record. Castle building RTS game Stronghold: Warlords has been delayed until March The start of the year is always a bit of a dry period, but the ongoing global health crises seems to be exacerbating the. They are adept at one aspect of leadership and they can be conducted diplomacy with by any player. Warlords are independent governors, who have their own fiefdoms and control their own castles. ![]() Din conturile sociale Facebook Google+ Twitter LinkedIn. Distribuie 'Stronghold: Warlords' unui prieten. The rest of the game is basically trebuchets raining death from afar, while the only actions the AI takes is instantly rebuilding the destroyed structures, a. Warlords are neutral players appearing alongside AI and human players in Stronghold Warlords. Twitch Intrai în cea mai mare comunitate de jocuri digitale din România. Originally slated to release on January 26th, it’s now been delayed to March 9th. To my great surprise, my enemy keeps using the same strategy of the last 15 minutes: produce 10-15 horse archers and send them my way. Firefly Studios’ Stronghold: Warlords has received another delay. ![]() Table 4: IAPWS coefficients and exponents of equation 1.įor Region 2 the model is also based on Gibbs free energy g. ![]() Table 3: Derived from g used in equations of Table 1. Table 2: Thermodynamic relations related to Gibbs free energy g and the corresponding adimensional equations. 1, and can be obtained from the equations representing this region included in section 2.4.Īll the thermodynamic properties can be derived from equation 1 following the equations outlined in Tables 2 and 3. Where p s(T) represents the pressure at saturation, Region 4 in Fig. N i, I i, J i= IAPWS coefficients and exponents included in Table 4.Įquation 1 covers the following ranges of pressure and temperature in Region 1 as shown in Fig. The basic equation for Region 1 is an equation for the Gibbs free energy g, expressed in the adimensional form: Table 1: Constants and properties of water Table 1 summarizes some of the constants and properties used in the model. Although the number of regions in the new model coincides with number in the previous model, some differences exist in the form in which the IFC-67 and IAPWS-IF97 models define the different regions. The IAPWS-IF97 model consists of a group of equations for a group of five graphical regions representing thermodynamic properties of water, and valid in the following ranges:įigure 1 shows the ranges within which the equations are valid, and the regions into which each range has been divided. The new model was considered officially valid beginning in 1997, but due to the need for modifying existing design procedures and computational program codes, the IAPWS recommended an introductory period lasting at least until the end of 1999 during which IAPWS-IF97 was not officially mandated. Each region requires the use of different equations, and furthermore the basic thermodynamic model chosen in relation to the interdependence of properties is not the same for each region.īased on these considerations, beginning in the decade of the 1980's, the International Association for the Properties of Water and Steam (IAPWS) decided to promote the development of a new series of investigations directed towards obtaining a new formulation for a model for the calculation of thermodynamic properties of water and steam, which was officially adopted in 1997 termed the "IAPWS Industrial Formulation 1997 for the Thermodynamic Properties of Water and Steam", subsequently known as IAPWS-IF97. It required division of the area of validity of its equations into five different regions due to the complexity of the behavior of the thermodynamic properties of water. The model was, however, was not easy to use. ![]() A great number of tables and diagrams existing in the literature, as well as computerized calculation programs were based on this model. Model IFC-67 was tested and recognized as reliable for the calculation of the thermodynamic properties of water. This model was developed from a variety of experimental data available for H 2O, which is the most abundant chemical compound in nature and also the most often used reagent in the chemical industry. In the decade of the 1960's a model was formulated for the calculation of thermodynamic properties of water for industrial use, and was known as the IFC-67 model. ![]() Keywords: thermodynamic properties, water and steam, calculation algorithms This paper presents the IAPWS-IF97 model in summarized form, and results obtained in applying it to the thermodynamic properties of water, including enthalpy, entropy, internal energy, and volume, in the states of compressed liquid, liquid-vapor equilibrium, and superheated steam, using calculation algorithms developed using common, universally available computational techniques. The new model is oriented toward facilitating calculations employing computers, improving accuracy, and improving consistency among the model's limiting regions as well as contributing towards improved process design and simulation. The latter model had been used for 30 years for the calculation of thermodynamic properties of water for industrial, scientific, and academic applications. Was recommended before replacing the current model which had been developed in the 1960's (IFC-67). This new model, termed IAPWS-IF97, was adopted beginning in 1997, but an evaluation and changeover period 2ġDepartment of Chemical Engineering, Engineering Faculty, Universidad de Antofagasta, Antofagasta, Chile,ĢDepartment of Chemistry, Basic Sciences Faculty, Universidad de Antofagasta, Antofagasta, Chile,īeginning in 2000 the International Association for the Properties of Water and Steam (IAPWS) recommended the use of a new model for calculation of the thermodynamic properties of water and steam. Soc., 51, Nº 2 (2006), pags: 891-900ĬALCULATION OF THE THERMODYNAMIC PROPERTIES OF WATER USING THE IAPWS MODEL 4/28/2023 0 Comments Dextran mr contrast![]() Tri-tyrosine residues distributed along the backbone. final compound 4 (PTriTyr) is a dextran based polymer with The addition of sodium cyanoborohydride (NaBH3CN). With the carbonyl groups via the primary amine to form a Schiff’sīase 3 which was further reduced in the same pot to an amine by The dark and the derivative named Pox 2 was obtained after Oxidised with sodium periodate (NaIO4) at room temperature in Possibility of using modified polysaccharides as targeting moietiesįor the imaging and/or treatment of vascular diseases.įirst, a dextran backbone already bearing Gd–DOTA 1 was Scheme 1 Synthesis of trityrosine bearing contrast agent. Modification, physical and chemical characterization, in vitro and W Electronic supplementary information (ESI) available: Chemical UMR 6270 & FR 3038 76821, Mont Saint Aignan, France Guerbet, Research Division, Aulnay-Sous-Bois, F-93600, France Universite´ Lyon 1, 43 Boulevard du 11 Novembre 1918, University Paris 7, Paris, F-75877, France Inserm, U698, Cardiovascular Bio-engineering, CHU X. Phenylalanines or tyrosines could generate a structure mimickingĭ-4F and, as a consequence, ApoA1 affinity to lipids, raising the This long circulating blood pool contrast agent isĭevoid of biospecificity for the arterial wall.14,15 We haveĬonsidered in the present work that the substitution of P717 with Substituted with carboxylate groups and Gd–DOTA13 (Scheme 1Īnd ESIw). Here the starting compound, named P717, is made of dextran Phenylalanine residues able to interact with lipids of lipoproteins11 Models.8–10 This product is a 18 amino acid peptide that formsĪn amphiphatic a-helix. Named ETC-216 or MDCO-216), show affinity to lipids.4–6 TheyĬould also self-assemble and link to apolipoproteins.7 Moreover,ĭ-4F has been shown to reduce the lipid core in vivo in animal (ApoA1) peptidomimetics, such as D-4F or ApoA1 milano (also Lipid core in the atherosclerotic plaque. Injection and have a lipophilic moiety to promote retention in the The MR contrast agent must be water soluble for intravascular Targeting the lipid core is challenging as Research activities have focused on contrast agents directedĪgainst plaque activity or inflammation markers such as macrophages or selectins,2,3 identifying the lipid rich necrotic core Great improvement for the patient follow-up.1 While major Identifying these plaques before they rupture would be a Main ischemic events are caused by the rupture of vulnerable plaques, composed of a large lipid core under a fine fibrousĬape. In vivo evaluation in mice of a new tri-tyrosine conjugated MRĬontrast agent, which may help to identify vulnerable plaques inĪtherosclerosis by targeting the lipid core.Ītherosclerosis is the leading cause of disease in western countries. This communication reports the synthesis, characterization and Received 14th February 2011, Accepted 16th March 2011 Luc Picton,e Didier Letourneurab and Frédéric Chaubetab Synthesis and evaluation of a tri-tyrosine decorated dextran MR contrastĪnne Beilvert,*ab Roger Vassy,ab Emmanuelle Canet-Soulas,c Olivier Rousseaux,d Downloaded by University of Chicago on 21:58:53. They are effectively internalised by human normal and cancer cells and demonstrate dose-dependent selective cytotoxicity to cancer cells.View Article Online / Journal Homepage / Table of Contents for this issueĬite this: Chem. These ultra-small (4–6 nm) Ce₀.₉Gd₀.₁O₁.₉₅ nanoparticles have been shown to possess excellent colloidal stability and high r₁-relaxivity (3.6 mM⁻¹ s⁻¹). Here, we report on a new type of theranostic MRI contrast, namely dextran stabilised, gadolinium doped cerium dioxide nanoparticles. Thus, there is an urgent need to develop a new generation of MRI contrasts that are safe and that have high selectivity in tissue accumulation with improved local contrast. The main causes of concern are possible gadolinium deposition in the brain and the development of systemic nephrogenic fibrosis after repeated use of MRI contrasts. The safety of previously approved contrast agents is questionable and is being re-assessed. 6586-6599 ISSN: 2050-7518 Subject: brain, ceric oxide, chemistry, cytotoxicity, dextran, dose response, fibrosis, gadolinium, humans, magnetism, nanoceria Abstract: Gd-based complexes are widely used as magnetic resonance imaging (MRI) contrast agents. Ivanov Source: Journal of materials chemistry B 2021 v.9 no.33 pp. Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T₁ relaxivity and selective cytotoxicity to cancer cells Author: A. 4/28/2023 0 Comments Good site to hold art filesThe image quality of raster files is measured in dots per inch (dpi) or pixels per inch (ppi). If you zoom in closely, you can see the pixels that make up a raster picture. Scans or photos taken on your phone or a digital camera are raster images. Raster images are made up of individually colored dots, called pixels. This article looks at raster files specifically. The file types are very different and are reviewed differently. Whether you are ordering screen print, embroidery or direct-to-garment printing, you will need one of two file types: either a high resolution raster file or a vector art file. Be familiar with the basics of raster files and art requirements for decoration.īasics Of Raster Files & Art Requirements.The information in this article is also available as a pdf download that can be saved or printed.Download the sample files to follow along on your computer. ![]() If you're new to digital art files you may want to get a little background on file types and art requirements.Basics of Raster File & Art Requirements. ![]() This article will provide the basic things you need to know about file types, getting set-up to view them, and how to know if they are a good quality for use. Looking at client art files is easy using our step-by-step instructions. Fact is, anyone with a computer can check the quality of a digital file for screenprint, embroidery, or DTG printing. You don’t need to be a graphic artist to know if the file your client sent is good to use for apparel decoration. 4/28/2023 0 Comments Spectre film soundtrack![]() It challenges the dominant but limited conception of film music as restricted to film by looking at its use in television and influence in the world of pop music and the traditional restriction of analysis to 'valued' film music, either from 'name' composers' or from the 'golden era' of Classical Hollywood. The author emphasises the manipulative and ephemeral character of film music dealing not only with traditional orchestral film music, but also looks at film music's colonisation of television, and discusses pop music in relation to films, and the historical dimensions to ability to possess audiences that have so many important cultural and aesthetic effects. RT Cool new visuals for new single, 'Stuck in the Middle'.This book is a major new study - dealing with notions of film music as a device that desires to control its audience, using a most powerful thing: emotion.RT People everywhere, a sense of expectation hanging in the air □.The piano version of this track is yours now. RT Once upon a time, I was Something to Someone.RT This week, our Campaign Director, has been in the press endorsing a brilliant new #dementia managem….Drake has just dropped his 7th studio album 'Honestly, Nevermind' □☀️. RT We are proud to be supporting #CelebrationDay this Sunday □ □.If you'd like to share who you'll be celebrating on June 26th, follow…. RT Want to share your #CelebrationDay story? □.brilliant new album, 'Denim & Rhinestones’, is album of the week! □. It’s so easy to take part! There’s just 3 simple steps: RT Want to get involved this Celebration Day? □.The two CD edition comes fully loaded with additional original scores and songs, including Scott Walker’s Only Myself To Blame and Shirley Bassey’s Mr Kiss Kiss Bang Bang. This release will be available in both single and double CD formats and brings together the finest theme tunes from all the Bond movies, including Louis Armstrong’s We Have All The Time In The World from On Her Majesty’s Secret Service to Paul McCartney & Wings’ Live And Let Die from the movie of the same name. “He’s so well known by soundtrack fans and with Sam Smith’s profile as well we are expecting a bigger audience,” she adds.Īlongside the release of the original Spectre score, Universal Music Catalogue is also issuing Best of Bond. Maunder Taylor says Newman’s reputation – he has scored major studio films including American Beauty, The Player and The Adjustment Bureau earning ten Academy Award nominations in the process – has already help Decca’s marketing. Further exposure will be directed at media outlets such as Classic FM, which has hosted an exclusive premiere of the soundtrack and whose Spectre page has been viewed nearly 20,000 times: an interview with Newman will also be aired on Charlotte Green’s Culture Club programme on October 25.īBC Radio 3 Sound of Cinema plans a Bond special on October 31 and other media, including the Guardian and Daily Telegraph, are being targeted to capture a wider audience of “music fans and Bond fans, who have seen the film”. The mostly online campaign will appear on YouTube and various social media sites. “Basically the marketing is around the track names because they are quite intriguing titles and we have used them in our graphics, which take their cues from the film but are a good way to differentiate the soundtrack from the bulk of information out there,” she says. Unusually named tracks by Newman include Tempus Fugit, Crows Klinik and Hinx, which Maunder Taylor says provided Decca with a way for the soundtrack to cut through other marketing around the film, which you cannot have missed stars Daniel Craig in the 24th outing for the British spy. ![]() Smith’s song Writing’s On The Wall has already racked up some impressive achievements – first number one chart hit for a Bond theme, 10million Spotify streams and 15m video views – and a different new orchestral version of the track is one of 26 cuts on the new soundtrack, scored by Grammy award-winning composer Thomas Newman.ĭecca product manager Amy Maunder Taylor explains the label has taken its lead from Newman for the album’s marketing because the composer, who also scored the BAFTA-winning soundtrack to previous Bond movie Skyfall, has penned some very idiosyncratic and distinctive-sounding track names. The releases from Decca and Universal Music Catalogue, coming three days before the UK premiere of the much anticipated Spectre film on October 26, coincide with an appearance by title song artist Sam Smith on the Graham Norton show. Universal Music has released two of the biggest ever James Bond-related music titles with the Spectre original soundtrack and a new collection of Bond theme tunes arriving today. |
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